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KMID : 0366220080430020083
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Korean Journal of Hematology
2008 Volume.43 No. 2 p.83 ~ p.88
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The Efficacy and Adverse Effect of Hydroxyurea as Compared with Anagrelide in Essential Thrombocythemia
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Seol Young-Mi
Kwon Bo-Ran
Choi Young-Jin
Lee Kyung-Woo
Shin Ho-Jin
Chung Joo-Seop
Lee Eun-Yup
Lee Won-Sik
Joo Young-Don
Cho Goon-Jae
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Abstract
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Background: Although the platelet count may not always correlate with the risk of thrombosis, there is evidence that a strict control of the platelet count decreases the incidence of thrombotic and hemorrhagic complications. However, it is difficult to select an appropriate platelet-lowering agent. This retrospective study was performed to assess the efficacy and adverse effect of the use of hydroxyurea and anagrelide for patients with essential thrombocythemia.
Methods: Sixty patients with essential thrombocythemia received either hydroxyurea (n=30) or anagrelide (n=30). Early responses and adverse effects of hydroxyurea and anagrelide in the patients were retrospectively analyzed.
Results: Treatment with anagrelide or hydroxyurea resulted in a rapid decrease of the platelet count within two weeks. The response rates after treatment with hydroxyurea and anagrelide were 83% and 77%, respectively. As compared with patients treated with hydroxyurea, patients treated with anagrelide presented with adverse effects such as headache palpitation was also frequently noticed (P=0.001). However, serious hemorrhage (n=2) and transformation to leukemia (n=1) occurred in patients treated with hydroxyurea.
Conclusion: Both anagrelide and hydroxyurea were effective and well-tolerated agents for the reduction of the platelet count. Long-term efficacy and adverse effects of the drugs remain to be determined.
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KEYWORD
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Essential thrombocythemia, Anagrelide, Hydroxyurea
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